PRKAB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CFE, 4CFF, 5EZV, 4ZHX,%%s4ZHX, 5EZV
Identifiers
Aliases	PRKAB1, AMPK, HAMPKb, protein kinase AMP-activated non-catalytic subunit beta 1
External IDs	OMIM: 602740 MGI: 1336167 HomoloGene: 38160 GeneCards: PRKAB1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 119,667,864 bp[1] End 119,681,624 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 116,151,645 bp[2] End 116,162,567 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum kidney body of stomach spleen renal medulla upper lobe of left lung body of pancreas right lung minor salivary gland left adrenal gland Top expressed in yolk sac secondary oocyte medullary collecting duct submandibular gland epithelium of stomach pyloric antrum right ventricle conjunctival fornix morula large intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity AMP-activated protein kinase activity protein binding protein kinase binding kinase activity Cellular component cytosol nucleotide-activated protein kinase complex nucleus nucleoplasm protein-containing complex cytoplasm Biological process protein heterooligomerization lipid metabolism fatty acid metabolic process protein phosphorylation positive regulation of gene expression fatty acid biosynthetic process regulation of catalytic activity macroautophagy nail development signal transduction positive regulation of cold-induced thermogenesis regulation of macroautophagy regulation of signal transduction by p53 class mediator phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5564 19079 Ensembl ENSG00000111725 ENSMUSG00000029513 UniProt Q9Y478 Q9R078 RefSeq (mRNA) NM_006253 NM_031869 RefSeq (protein) NP_006244 NP_006244.2 NP_114075 Location (UCSC) Chr 12: 119.67 – 119.68 Mb Chr 5: 116.15 – 116.16 Mb PubMed search [3] [4]
Wikidata
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5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.^[5][6]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.^[6]

Interactions

PRKAB1 has been shown to interact with PRKAG2^[7] and PRKAG1.^[7]

The 5'-AMP-activated protein kinase beta subunit interaction domain (AMPKBI) is a conserved domain found in the beta subunit of the 5-AMP-activated protein kinase complex, and its yeast homologues Sip1 (SNF1-interacting protein 1), Sip2 (SNF1-interacting protein 2) and Gal83 (galactose metabolism 83), which are found in the SNF1 (sucrose non-fermenting) kinase complex.^[8] This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known.^[9]