STK10
PBB Protein STK10 image.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTK10, LOK, PRO2729, serine/threonine kinase 10
External IDsOMIM: 603919 MGI: 1099439 HomoloGene: 38122 GeneCards: STK10
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005990

NM_009288
NM_001359177
NM_001359178

RefSeq (protein)

NP_005981

NP_033314
NP_001346106
NP_001346107

Location (UCSC)Chr 5: 172.04 – 172.19 MbChr 11: 32.48 – 32.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[5][6]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072786 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020272 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics. 49 (5): 369–75. doi:10.1007/s002510050509. PMID 10199912. S2CID 877572.
  6. ^ a b "Entrez Gene: STK10 serine/threonine kinase 10".

Further reading