AliasesCDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1, cyclin-dependent kinase 11B, cyclin dependent kinase 11B
External IDsOMIM: 176873 HomoloGene: 137644 GeneCards: CDK11B
EC number2.7.11.22
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 1: 1.64 – 1.66 Mbn/a
PubMed search[2]n/a
View/Edit Human

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDK11B gene.[3][4][5]

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.[5]


CDC2L1 has been shown to interact with Cyclin D3.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000248333 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Eipers PG, Barnoski BL, Han J, Carroll AJ, Kidd VJ (Mar 1992). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15". Genomics. 11 (3): 621–9. doi:10.1016/0888-7543(91)90069-Q. PMID 1774066.
  4. ^ Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M (Sep 2003). "The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM". Biochem. Biophys. Res. Commun. 310 (1): 14–8. doi:10.1016/j.bbrc.2003.08.116. PMID 14511641.
  5. ^ a b "Entrez Gene: CDC2L1 cell division cycle 2-like 1 (PITSLRE proteins)".
  6. ^ Zhang, Songwen; Cai Mingmei; Zhang Si; Xu Songli; Chen She; Chen Xiaoning; Chen Chun; Gu Jianxin (Sep 2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314–22. doi:10.1074/jbc.M202179200. ISSN 0021-9258. PMID 12082095.

Further reading