MAPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I
Identifiers
Aliases	MAPK1, ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, mitogen-activated protein kinase 1, NS13
External IDs	OMIM: 176948 MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.22 Start 21,759,657 bp[1] End 21,867,680 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 10.53 cM Start 16,801,246 bp[2] End 16,865,317 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus postcentral gyrus Brodmann area 23 entorhinal cortex superior frontal gyrus external globus pallidus pons visceral pleura superior vestibular nucleus subthalamic nucleus Top expressed in olfactory tubercle superior frontal gyrus entorhinal cortex hippocampus proper amygdala primary motor cortex subiculum cingulate gyrus nucleus accumbens prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatase binding ATP binding protein kinase activity transcription factor binding transferase activity mitogen-activated protein kinase kinase kinase binding phosphotyrosine residue binding protein binding protein kinase binding DNA binding nucleotide binding RNA polymerase II CTD heptapeptide repeat kinase activity protein serine/threonine kinase activity kinase activity identical protein binding MAP kinase activity double-stranded DNA binding MAP kinase kinase activity Cellular component cytoplasm cytosol focal adhesion microtubule organizing center mitochondrion caveola dendrite cytoplasm cytoskeleton nucleus extracellular exosome perikaryon late endosome Golgi apparatus spindle axon early endosome mitotic spindle pseudopodium extracellular region nucleoplasm azurophil granule lumen ficolin-1-rich granule lumen plasma membrane postsynaptic density membrane protein-containing complex Biological process caveolin-mediated endocytosis positive regulation of telomere capping response to exogenous dsRNA cardiac neural crest cell development involved in heart development positive regulation of translation cellular response to DNA damage stimulus platelet activation Fc-epsilon receptor signaling pathway protein phosphorylation face development cellular response to granulocyte macrophage colony-stimulating factor stimulus regulation of DNA-binding transcription factor activity animal organ morphogenesis cell cycle ERBB signaling pathway apoptotic process B cell receptor signaling pathway regulation of transcription, DNA-templated regulation of protein stability Fc-gamma receptor signaling pathway involved in phagocytosis thymus development negative regulation of cell differentiation ERK1 and ERK2 cascade labyrinthine layer blood vessel development transcription, DNA-templated positive regulation of transcription, DNA-templated heart development viral process response to toxic substance regulation of stress-activated MAPK cascade chemical synaptic transmission growth hormone receptor signaling pathway via JAK-STAT cytosine metabolic process phosphorylation outer ear morphogenesis response to estrogen chemotaxis response to lipopolysaccharide thyroid gland development response to epidermal growth factor positive regulation of telomerase activity sensory perception of pain peptidyl-threonine phosphorylation trachea formation lipopolysaccharide-mediated signaling pathway mammary gland epithelial cell proliferation intracellular signal transduction lung morphogenesis neural crest cell development positive regulation of cell migration regulation of early endosome to late endosome transport response to stress positive regulation of telomere maintenance via telomerase MAPK cascade axon guidance fibroblast growth factor receptor signaling pathway positive regulation of peptidyl-threonine phosphorylation peptidyl-serine phosphorylation positive regulation of cell population proliferation regulation of cellular response to heat Bergmann glial cell differentiation regulation of Golgi inheritance T cell receptor signaling pathway regulation of cytoskeleton organization signal transduction long-term potentiation regulation of ossification regulation of phosphatidylinositol 3-kinase signaling neutrophil degranulation regulation of gene expression cellular response to organic substance human ageing learning or memory positive regulation of gene expression diadenosine tetraphosphate biosynthetic process regulation of cellular pH cellular response to amino acid starvation cellular response to reactive oxygen species response to nicotine decidualization stress-activated MAPK cascade positive regulation of cardiac muscle cell proliferation cellular response to cadmium ion cellular response to tumor necrosis factor cellular response to dopamine positive regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5594 26413 Ensembl ENSG00000100030 ENSMUSG00000063358 UniProt P28482 P63085 RefSeq (mRNA) NM_138957 NM_002745 NM_001038663 NM_011949 NM_001357115 NM_028991 RefSeq (protein) NP_002736 NP_620407 NP_001033752 NP_036079 NP_001344044 Location (UCSC) Chr 22: 21.76 – 21.87 Mb Chr 16: 16.8 – 16.87 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.^[5]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.^[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.^[7]

Interactions

MAPK1 has been shown to interact with:

Clinical significance

Mutations in MAPK1 are implicated in many types of cancer.^[46]