Available structures
PDBOrtholog search: PDBe RCSB
AliasesRPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
External IDsOMIM: 603607 MGI: 1920336 HomoloGene: 48302 GeneCards: RPS6KA5
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 14: 90.85 – 91.06 MbChr 12: 100.51 – 100.69 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.[5][6][7] This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.[8][9]


RPS6KA5 has been shown to interact with CREB1.[5][10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100784Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021180Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
  6. ^ Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenet Cell Genet. 87 (3–4): 261–2. doi:10.1159/000015441. PMID 10702687. S2CID 10527498.
  7. ^ "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".
  8. ^ Soloaga, Ana; Thomson, Stuart; Wiggin, Giselle R.; Rampersaud, Navita; Dyson, Mark H.; Hazzalin, Catherine A.; Mahadevan, Louis C.; Arthur, J.Simon C. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. ISSN 0261-4189. PMC 156769. PMID 12773393.
  9. ^ Reul, Johannes M. H. M.; Chandramohan, Yalini (2007-08-01). "Epigenetic mechanisms in stress-related memory formation". Psychoneuroendocrinology. Integrative approaches to neural plasticity (Lille Summer School, 2006). 32: S21–S25. doi:10.1016/j.psyneuen.2007.03.016. ISSN 0306-4530. PMID 17644269. S2CID 24217924.
  10. ^ Wang, X; Li W; Williams M; Terada N; Alessi D R; Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". EMBO J. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

Further reading