Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8gene.[5][6]
Function
The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported.[7] MAPK8 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abDérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (April 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell. 76 (6): 1025–37. doi:10.1016/0092-8674(94)90380-8. PMID8137421. S2CID6797795.
^Cano E, Hazzalin CA, Kardalinou E, Buckle RS, Mahadevan LC (November 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell Sci. 108 (11): 3599–609. doi:10.1242/jcs.108.11.3599. PMID8586671.
1jnk: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
1pmn: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
1pmq: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
1pmu: The crystal structure of JNK3 in complex with a phenantroline inhibitor
1pmv: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
1ukh: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
1uki: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
2b1p: inhibitor complex of JNK3
2exc: Inhibitor complex of JNK3
2g01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
2gmx: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
2no3: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
2o0u: Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
2o2u: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
2ok1: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)