Available structures
PDBOrtholog search: PDBe RCSB
AliasesMAPKAPK3, 3PK, MAPKAP-K3, MAPKAP3, MAPKAPK-3, MK-3, mitogen-activated protein kinase-activated protein kinase 3, MDPT3, MAPK activated protein kinase 3, MK3
External IDsOMIM: 602130 MGI: 2143163 HomoloGene: 55836 GeneCards: MAPKAPK3
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 50.61 – 50.65 MbChr 9: 107.13 – 107.17 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.[5][6][7]


This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.[7]


MAPKAPK3 has been shown to interact with MAPK14[8] and TCF3.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114738Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032577Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR (June 1996). "Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase". J Biol Chem. 271 (14): 8488–92. doi:10.1074/jbc.271.14.8488. PMID 8626550.
  6. ^ Sithanandam G, Latif F, Duh FM, Bernal R, Smola U, Li H, Kuzmin I, Wixler V, Geil L, Shrestha S (June 1996). "3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region". Mol Cell Biol. 16 (3): 868–76. doi:10.1128/mcb.16.3.868. PMC 231067. PMID 8622688.
  7. ^ a b "Entrez Gene: MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3".
  8. ^ Tanoue T, Maeda R, Adachi M, Nishida E (February 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. 20 (3): 466–79. doi:10.1093/emboj/20.3.466. PMC 133461. PMID 11157753.
  9. ^ Neufeld B, Grosse-Wilde A, Hoffmeyer A, Jordan BW, Chen P, Dinev D, Ludwig S, Rapp UR (July 2000). "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity". J. Biol. Chem. 275 (27): 20239–42. doi:10.1074/jbc.C901040199. PMID 10781029.

Further reading