MAPK13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3COI, 4EYJ, 4EYM, 4MYG, 4YNO, 5EKO, 5EKN
Identifiers
Aliases	MAPK13, MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta, mitogen-activated protein kinase 13
External IDs	OMIM: 602899 MGI: 1346864 HomoloGene: 48133 GeneCards: MAPK13
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 36,127,809 bp[1] End 36,144,524 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 28,988,271 bp[2] End 28,999,207 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums right adrenal gland left adrenal gland human penis parotid gland vulva sperm duodenum oral cavity skin of abdomen Top expressed in lip crypt of lieberkuhn of small intestine epithelium of stomach duodenum large intestine ileum colon intestinal villus jejunum left colon More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity MAP kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytosol nucleus cytoplasm Biological process positive regulation of inflammatory response regulation of transcription, DNA-templated phosphorylation transcription, DNA-templated response to osmotic stress protein phosphorylation peptidyl-serine phosphorylation positive regulation of interleukin-6 production cell cycle regulation of gene expression cellular response to UV stress-activated MAPK cascade cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to sorbitol cellular response to anisomycin cellular response to sodium arsenite MAPK cascade intracellular signal transduction cellular response to organic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5603 26415 Ensembl ENSG00000156711 ENSMUSG00000004864 UniProt O15264 Q9Z1B7 RefSeq (mRNA) NM_002754 NM_011950 RefSeq (protein) NP_002745 NP_036080 Location (UCSC) Chr 6: 36.13 – 36.14 Mb Chr 17: 28.99 – 29 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.^[5]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.^[5]