MARK4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D, microtubule affinity regulating kinase 4
External IDsOMIM: 606495 MGI: 1920955 HomoloGene: 57146 GeneCards: MARK4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199867
NM_031417

NM_172279
NM_001368427

RefSeq (protein)

NP_001186796
NP_113605

NP_758483
NP_001355356

Location (UCSC)Chr 19: 45.08 – 45.31 MbChr 7: 19.16 – 19.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.[5][6][7] MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules.[8] Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.[9]

There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau protein in this disease.

Interactions

MARK4 has been shown to interact with USP9X[10] and Ubiquitin C.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007047 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030397 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y (Apr 2001). "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis". Neoplasia. 3 (1): 4–9. doi:10.1038/sj.neo.7900132. PMC 1505019. PMID 11326310.
  6. ^ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.
  7. ^ "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4".
  8. ^ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/s0092-8674(00)80208-1. PMID 9108484.
  9. ^ Naz F, Anjum F, Islam A, Ahmad F, Hassan MI (November 2013). "Microtubule affinity-regulating kinase 4: structure, function, and regulation". Cell Biochemistry and Biophysics. 67 (2): 485–99. doi:10.1007/s12013-013-9550-7. PMID 23471664. S2CID 13507976.
  10. ^ a b Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (April 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains" (PDF). The Biochemical Journal. 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724.

Further reading