CDK10
Identifiers
AliasesCDK10, PISSLRE, cyclin-dependent kinase 10, cyclin dependent kinase 10, ALSAS
External IDsOMIM: 603464 MGI: 2448549 HomoloGene: 55769 GeneCards: CDK10
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098533
NM_001160367
NM_003674
NM_052987
NM_052988

NM_194444
NM_194446

RefSeq (protein)

NP_001092003
NP_001153839
NP_443713
NP_443714

NP_919426
NP_919428

Location (UCSC)Chr 16: 89.68 – 89.7 MbChr 8: 123.95 – 123.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.[5][6][7]

Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.[7]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185324 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033862 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene. 9 (7): 2097–103. PMID 8208557.
  6. ^ Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene. 9 (10): 3037–41. PMID 8084611.
  7. ^ a b "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10".
  8. ^ Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. S2CID 22792083.

Further reading