Available structures
PDBOrtholog search: PDBe RCSB
AliasesSTK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
External IDsOMIM: 604965 MGI: 1929004 HomoloGene: 55965 GeneCards: STK4
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 20: 44.97 – 45.08 MbChr 2: 163.91 – 164 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.[5][6][7]


The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p (sterile 20 protein) kinase, which acts upstream of the stress-induced mitogen-activated protein kinase (MAPK) cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.[8]


STK4 has been shown to interact with PRKRIR.[9]

STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101109Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018209Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. Bibcode:1996PNAS...9310099T. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
  6. ^ Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. doi:10.1093/emboj/17.8.2224. PMC 1170567. PMID 9545236.
  7. ^ Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. Bibcode:2001PNAS...9810148U. doi:10.1073/pnas.181161698. PMC 56930. PMID 11517310.
  8. ^ "Entrez Gene: STK4 serine/threonine kinase 4".
  9. ^ Lin Y, Khokhlatchev A, Figeys D, Avruch J (December 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. PMID 12384512.
  10. ^ Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G (2014). "Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers" (PDF). Nat. Med. 20 (6): 599–606. doi:10.1038/nm.3562. PMC 4057660. PMID 24813251.

Further reading