Receptor protein serine/threonine kinase
Identifiers
SymbolReceptor protein serine/threonine kinase
Membranome3
Receptor protein serine/threonine kinase
Identifiers
EC no.2.7.11.30
CAS no.146702-86-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Receptor protein serine/threonine kinases (EC 2.7.11.30) are enzyme-linked receptors that belong to protein-serine/threonine kinases. The systematic name of this enzyme class is ATP:[receptor-protein] phosphotransferase. Proteins from this group participate in 7 metabolic pathways: MAPK signaling pathway, cytokine-cytokine receptor interaction, TGF beta signaling pathway, adherens junction, colorectal cancer, pancreatic cancer, and chronic myeloid leukemia.

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References

  • Wrana JL, Attisano L, Wieser R, Ventura F, Massague J (1994). "Mechanism of activation of the TGF-beta receptor". Nature. 370 (6488): 341–7. Bibcode:1994Natur.370..341W. doi:10.1038/370341a0. PMID 8047140. S2CID 4344481.
  • Massague J, Chen YG (2000). "Controlling TGF-beta signaling". Genes Dev. 14 (6): 627–44. PMID 10733523.
  • Lechleider RJ; Hemmati, P; Larisch-Bloch, S; Ajmera, R; Roberts, AB; Lechleider, RJ (1997). "Characterization of functional domains within Smad4/DPC4". J. Biol. Chem. 272 (21): 13690–6. doi:10.1074/jbc.272.21.13690. PMID 9153220.


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