Protein-coding gene in the species Homo sapiens
Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene .[5] [6]
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family and participates in the Hippo signaling pathway where it inactivates the effector proteins, YAP and WWTR1 (TAZ) . The protein localizes to centrosomes during interphase and early and late metaphase . It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis . It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a corepressor of androgen-responsive gene expression.[6]
^ a b c GRCh38: Ensembl release 89: ENSG00000150457 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021959 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics . 63 (2): 263–70. doi :10.1006/geno.1999.6065 . PMID 10673337 . ^ a b "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)" .
Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000). "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor" . Oncogene . 19 (27): 3101–9. doi :10.1038/sj.onc.1203659 PMID 10871863 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Li Y, Pei J, Xia H, et al. (2003). "Lats2, a putative tumor suppressor, inhibits G1/S transition" . Oncogene . 22 (28): 4398–405. doi :10.1038/sj.onc.1206603 PMID 12853976 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Powzaniuk M, McElwee-Witmer S, Vogel RL, et al. (2005). "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor" . Mol. Endocrinol . 18 (8): 2011–23. doi :10.1210/me.2004-0065 PMID 15131260 . Toji S, Yabuta N, Hosomi T, et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase" . Genes Cells . 9 (5): 383–97. doi :10.1111/j.1356-9597.2004.00732.x PMID 15147269 . Ke H, Pei J, Ni Z, et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)". Exp. Cell Res . 298 (2): 329–38. doi :10.1016/j.yexcr.2004.04.031 . PMID 15265683 . Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene . 24 (12): 2076–86. doi :10.1038/sj.onc.1208445 . PMID 15688006 . S2CID 27285160 . Takahashi Y, Miyoshi Y, Takahata C, et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers" . Clin. Cancer Res . 11 (4): 1380–5. doi :10.1158/1078-0432.CCR-04-1773 PMID 15746036 . Abe Y, Ohsugi M, Haraguchi K, et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis" . FEBS Lett . 580 (3): 782–8. doi :10.1016/j.febslet.2005.12.096 PMID 16413547 . Voorhoeve PM, le Sage C, Schrier M, et al. (2006). "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors" . Cell . 124 (6): 1169–81. doi :10.1016/j.cell.2006.02.037 PMID 16564011 . Aylon Y, Michael D, Shmueli A, et al. (2007). "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization" . Genes Dev . 20 (19): 2687–700. doi :10.1101/gad.1447006 . PMC 1578695 PMID 17015431 . Jiang Z, Li X, Hu J, et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma". Neurosci. Res . 56 (4): 450–8. doi :10.1016/j.neures.2006.09.006 . PMID 17049657 . S2CID 22763208 .
Activity Regulation Classification Kinetics Types
