TPK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTPK1, HPP20, THMD5, thiamin pyrophosphokinase 1
External IDsOMIM: 606370 MGI: 1352500 HomoloGene: 6960 GeneCards: TPK1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013861
NM_001311111

RefSeq (protein)

NP_001298040
NP_038889

Location (UCSC)Chr 7: 144.45 – 144.84 MbChr 6: 43.32 – 43.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.[5][6]

This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196511 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029735 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta. 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID 11342111.
  6. ^ a b "Entrez Gene: TPK1 thiamin pyrophosphokinase 1".

Further reading