DAPK3
Protein DAPK3 PDB 1yrp.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDsOMIM: 603289 MGI: 1203520 HomoloGene: 20353 GeneCards: DAPK3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001348
NM_001375658

NM_001190473
NM_001190474
NM_007828

RefSeq (protein)

NP_001339
NP_001362587

NP_001177402
NP_001177403
NP_031854

Location (UCSC)Chr 19: 3.96 – 3.97 MbChr 10: 81.02 – 81.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[5][6]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[6]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[7]

Interactions

DAPK3 has been shown to interact with PAWR[8] and Death associated protein 6.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167657 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034974 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
  6. ^ a b "Entrez Gene: DAPK3 death-associated protein kinase 3".
  7. ^ Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
  8. ^ a b Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Further reading